|
KMID : 0043320070300030299
|
|
Archives of Pharmacal Research
2007 Volume.30 No. 3 p.299 ~ p.302
|
|
|
Farnesyl Protein Transferase and Tumor Cell Growth Inhibitory Activities of Lipiferolide Isolated from Liriodendron tulipifera
|
|
Moon Mi-Kyeong
Oh Hyun-Mi
Kwon Byoung-Mog
Baek Nam-In
Kim Sung-Hoon
Kim Ju-Sin
Kim Dae-Keun
|
|
|
Abstract
|
|
|
|
The methanolic extract of the leaves of Liriodendron tulipifera was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of lipiferolide, an inhibitor of FPTase. This compound inhibited the FPTase activity in a dose-dependent manner, and showed cell growth inhibitory activity against several tumor cells.
|
|
|
KEYWORD
|
|
|
Liriodendron tulipifera, Lipiferolide, FPTase, Cell growth inhibitory activity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|